I usually take 20 mg adderall in the morning anytime from 8-9:30 am. The therapeutic effects for the 4 hours that it’s sold as lasting. The problem is that I have difficulty falling asleep 1-2 hours past my bed time.

And I’m going to have to start taking it in the afternoon. I’ve heard eating citrus helps counteract the effects. I’ve tried melatonin, which has helped to a degree

  • Sulvy [he/him, comrade/them]@hexbear.netEnglish
    10·
    9 days ago

    For anyone reading, it is the acidity in your stomach from something like orange juice that alters the uptake of amphetamines. Adderall, for example, is a weak base which becomes more ionized in a highly acidic environment and cannot pass through membranes as well.

    • Lussy [he/him, des/pair]@hexbear.netOPEnglish
      3·
      8 days ago

      My question is does Vitamin C only have its effect on the drug during uptake and not after several hours of the drug having passed through your body?

      • Sulvy [he/him, comrade/them]@hexbear.netEnglish
        4·
        8 days ago

        Only during uptake. Once it’s in your bloodstream, the acidity of your stomach and small intestine will no longer play a factor.

        I would say uptake happens over 2 hours at most, especially if you’ve just eaten a large meal

      • baahb@lemmy.dbzer0.comEnglish
        4·
        8 days ago

        No no no and no.

        Vitamin C doesn’t do shit.

        Citric acid, when in contact with the physical pill, will break it down.

        Once there is no more pill, cause its been metabolized, the citric acid in your stomach doesn’t affect it any more.

        Once you’ve metabolized it, you’ve metabolized it.

        • Sulvy [he/him, comrade/them]@hexbear.netEnglish
          5·
          8 days ago

          This is only half right, vitamin C does increase the acidity of your stomach. And it is not the physical breakdown of the pill, but how the increased hydrogen ions (H+) bind with the amphetamine molecules and prevent them from crossing your lipophilic GI membranes.

          • baahb@lemmy.dbzer0.comEnglish
            3·
            8 days ago

            Dope. I’m super not into chemistry, but I saw enough misconception to try and clean up before someone started trying to offset drugs with drugs.

            So, lemme poke this a bit…

            First, its basically any acid. But stronger means higher impact. Vitamin C is not the important chemical, but it does increase the effect cause its stronger than stomach acid?

            Lipophilic… Fat loving… Okay so in the stomach the acid works to neutralize the adderol, but higher acidity means more ionization which makes it harder to absorb through your stomach or intestinal lining?

            Are those assumptoons correct?

            Still thiygh, once your body has metabolized the adderol into your blood stream, you gotta deal with it being in your blood stream.