Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity

Thank you for the reference, it was a interesting read. This study has the Saturated fat group at 50% saturated fat, and 50% unsaturated fats, its not a very clean signal. I’m not sure why the SAFA group had a reduced response to a GTT, it warrants further study.

Since the study you reference is from 2001, there are more recent studies that reference it.

https://www.sciencedirect.com/science/article/pii/S2161831323000674

Saturated Fatty Acid Intake and Risk of Type 2 Diabetes: An Updated Systematic Review and Dose–Response Meta-Analysis of Cohort Studies

There was evidence of publication bias among studies on dietary total SFAs and T2DM. Our results indicated no significant association between dietary total SFA and risk of T2DM.

Some of the experimental studies support the notion that dietary fats, and SFAs in particular, are associated with the development of insulin resistance and type 2 diabetes mellitus (T2DM) (2–5). On the other hand, the majority of more recent cohort studies have indicated no association between dietary SFAs and the incidence of T2DM

The linear dose–response meta-analysis of the main 13 studies showed no linear association between increasing intake of SFAs and T2DM risk (HR: 0.93; 95% CI: 0.84, 1.03). From 13 cohort studies regarding the association between total SFAs and T2DM risk, 7 studies (5–7, 9, 31, 33, 34) reported sufficient data for the nonlinear doseresponse analyses. There was no evidence of a U- or J-shaped association between total SFA intake and risk of T2DM (Pnonlinearity = 0.153; n = 7; Figure 3). Supplemental Figure 5 presents the results for publication bias. Overall, there was evidence of publication bias with the Egger test (P = 0.032).