I'd say the stopping thing is a few multiplayer PvP games with anticheat, also some software that won't work in Wine (adobe products, corel products, microsoft products).
Yes, I know alternatives exist (Krita, Inkscape, LibreOffice). No, they are not 100% drop-in replacements. I for myself love working in LibreOffice Writer, but when you work in a place where everyone except you uses MS Word and expects DOCX files, you can't "just" switch to linux without issue.


I like inkscape but snapping is terrible. In corel I just drag whatever I need with my mouse and it just snaps to where I need it to be. I always thought this is fairly simple and standard but when I tried snapping in Inkscape, it always tries to snap to something on the other half of the document.
I need to constantly change snapping options to make it work whereas in corel I enabled all the options, set and forget thing, it just does what I want every time, as if it's reading my mind, without the need to toggle snapping options every time.