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squaresinger

@ squaresinger @lemmy.world

Posts
21
Comments
3009
Joined
11 mo. ago

  • Please science

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  • Weirdly, they administered sildanefil vaginally. You'll need a pharmacist and a laboritory to create sildenafil vaginal suppositories, so a bit above grad school level.

    Still something that any pharmacy can do for a low price. They only need to grind up regular sildanefil pills and put the powder into vaginal suppositories.

    Our pharmacy did something similar for anal suppositories for our baby when there were covid-related shortages for ibuprofen suppositories.

  • How to become a team/department lead?

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  • As lower/middle management, you are crushed from both sides. Upper management demands from you what to do, and the people under you hate what you are forced to implement. It's actually really annoying and difficult. I was department lead and went back to just developing.

  • My country's police just busted a dangerous 3d printed weapons manufacturer.

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  • This is the really weird thing. If these knives were made of metal and in a kitchen drawer, nobody would think of them as being weapons. But since they are 3d printed, that's novel enough to warrant some panic or something...

  • TIL getting married young during the European Medieval times was rare.

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  • Once again a reminder that the "experienced past", so the way we think the past worked, only covers a very short timeframe.

  • Please science

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  • I wonder if actually helpful PMS medication would cannibalize e.g. pain medication sales. Generic viagra is super cheap, and in the study they used just one dose. So if that's the actual dosage required in the end, that could cost the pharmaceuticals industry money.

    Similar to with vas occlusive contraception. It's really easy, simple, dirt cheap, lasts long, is reversible, non-hormonal, no side effects male contraception. It's basically the perfect contraception and it's the only reversible long-term contraception that men can use.

    But it was dropped because it would pretty much annihilate the female contraceptive industry, which makes a huge amount of money each year.

    Quote from the Wiki article on RISUG, the form of Vas-occlusive contraception that came closest to getting to market:

    Despite this, pharmaceutical companies are reluctant to lose market share of a thriving global market for female contraceptives and condoms which bring billions of dollars of revenue each year. Initially, RISUG attracted some interest from pharmaceutical companies. However, considering that RISUG is an inexpensive, one-time procedure, manufacturers retracted.

    https://en.wikipedia.org/wiki/Reversible_inhibition_of_sperm_under_guidance

  • All Games Are Going Somewhere or Cleaning Something

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  • If you reduce any game to its core loop, all of them are pretty simplistic. That's just what happens if you simplify things ad absurdum.

    • Counter strike is just running around and shooting people
    • BoTW is just walking around, killing monsters and replacing broken weapons
    • Need for speed is just driving
    • Factorio is just automating everything

    And all these things are nothing but tasks.

    That said, while this is pretty lame critique, that doesn't mean that every game is good and it also doesn't mean that every game is good for every player.

  • Can't unsee the eye

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  • Yes

  • Please science

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  • Probably something like that... Sucks.

    And it's kinda stupid too. PMS is well known to not be conductive to female libido, and female libido is conductive to Viagra sales. So why not sell it to women too (=more sales) which might increase the occasions to sell it to men as well.

  • Friendly reminder that these aren't European (anymore)

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  • The brand name also includes “Berne,” which is the historical English spelling for the city of Bern.

    The brand name also includes "Bern", which is the historical German spelling for the city of Bern.

  • Please science

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  • However, the trial ended prematurely as investigators did not meet their sample size, so the funding was discontinued.

    How? Why? This kind of study should be trivially easy to complete. The medication is already on the market, generics are super cheap, administration is super simple and non-invasive and I'd guess there are plenty of women suffering from PMS. That sounds like the kind of study that a grad student could pull off on a DIY budget.

    According to Google, generics are ~€0.50 per dose and they administered a single dose per patient. Let's say placebos cost the same as the generics, then the cost for these 25 participants was less than €15.

  • Please science

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  • Heroin was developed as a painkiller and cough remedy.

    Nowadays it's only sold for the fun side effects.

  • in all fairness italian cuisine is a relatively recent invention

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  • Tbh, british food is mostly just salt-deficient. Add salt to it and a lot of it tastes really good.

  • is skeuomorphism still applicable if the symbol has lost meaning to most?

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  • Judging by skeuomorphic icons that got stuck in the past, they usually get stuck with the last iteration of tech that is single-purpose and unambiguous.

    For example, the icon for "train" is most often a steam train, even though they haven't been common for a very long time. But there's nothing else that looks like a steam train, while a diesel/electric train just looks like a generic box when on a small, low-resolution icon.

    The disk icon for saving got stuck because it's the last piece of storage tech with a clearly recognizable shape. SD cards are just rectangles, hard drives or SSDs also don't really have a clearly recognizable shape (especially not to someone who has never taking a PC apart).

    But the floppy disk icon won against e.g. drum storage (which is sometimes still used as an icon for databases) or tape storage, because it was newer and more widely used.

    The landline phone icon wasn't replaced by a smartphone, because the smartphone isn't single-use. It's ambiguous what e.g. an app with a smartphone icon would do, since a smartphone can be used for a ton of different things.

    So in short, an icon gets stuck with the

    • newest tech
    • that is single-use
    • that has a clearly recognizable shape

    From then it stops mattering whether the tech depicted is still in use or even known by the youngest generation. It's now not the "floppy disk icon" but the "save icon" instead.

  • Toyota Owner Didn’t Know His Car Was Talking To Insurers Until He Saw His Rates

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  • The reason why fines currently have to be so high is because drivers aren't caught in 99+% of cases when they break the law.

    You can speed all day every day and only get caught once a month, so the fine needs to be high to compensate for the low rate of getting caught.

    If you get caught every single time you do something wrong, that means that someone who routinely ignores the laws will accumulate high fines while someone who drives well but made a mistake once doesn't get high fines.

    Imagine this scenario: You missed a speed limit sign. Your in car entertainment system beeps and shows a small message: "Too fast, €2". You immediately reduce your speed and comply with the law.

    Alternatively, you ignore the message and continue to drive too fast. Every few seconds the system beeps again and fines you another €2. By the end of the trip you racked up €200 in fines.

    That's a much fairer system than the current one where missing one speed limit sign once can cost you a lot of money while someone who memorized the locations of the speed cameras can get away with speeding all the time without getting caught.

  • Billion-times more efficient nuclear fusion could be unlocked with low-frequency lasers

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  • Well, if it was real science, then popscience links like interestingengineering.com wouldn't be allowed. Instead, research papers would be linked directly.

  • Why do people always talk about Ubuntu here instead of Kubuntu?

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  • It's immutable Fedora. Immutability is something that not even regular Fedora uses, because it causes weirdness and potential trouble if you don't just use it as a wrapper for flatpak.

  • The 2026 Linux Summer Games - Dankpods compares performance in games across Windows and Linux on 12 machines

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  • This.

    The only point of brazzite is that you don't have to spend hours setting up, configuring and debugging. If that doesn't work, there is no point in using brazzite.

  • Billion-times more efficient nuclear fusion could be unlocked with low-frequency lasers

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  • Yeah, but c/science is popscience not real science.

  • The 2026 Linux Summer Games - Dankpods compares performance in games across Windows and Linux on 12 machines

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  • That's the issue though. When everything works it's great. But it's so easy to bungle something up (be it user error or bugs in distros).

    I'm running a 4070. Performance is really nice. Modern games pinned at vsync speed of 144FPS. The next day I'm down to 0.2FPS. Stays like that for a few days. Reboots don't help. Can't find anything debugging or googleing. After a few days it's back up.

    Turns out, I run games through heroic installed via flatpak, and flatpak keeps its own copy of Nvidia drivers. That version needs to be perfectly in sync with the system driver version. So dnf update breaks that and the games fall back to CPU rendering, and flatpak update plus reboot fixes it again. Running flatpak update first followed by dnf update makes sure performance always sucks.

    Took me a very long time to figure that out, and I imagine someone without an IT background might never figure that out.