It's possible they haven't discovered why yet.So far, I've found two things.
The pyroptosis pathway triggered is the typical one (lots of Caspase-1 proteins get assembled into a giant inflammosome complex and attack Gasdermin D, which then starts poking holes in the cell membrane).
The EPS3.9 molecule has a high affinity for a five separate membrane lipids.
But without any formal biochemistry training, I am missing a lot of prerequisite knowledge.
Is that high affinity above normal? Does it need to bind all five to enter the cell, or just any of them? Are those lipids, or that combination of lipids, exclusive to tumor cells? I have no info on any of these questions.
It's also entirely possible that it's attacking healthy liver cells too, just at a reduced rate due to cancer cells being resource hogs.
Walkable and bikeable, please. While it is nice to be able to exercise and explore, sometimes I just need to transport a few bags worth of groceries, and carrying bags for over an hour is not fun.I'll take a bike and some pannier bags please.
Additionally, any driver traveling more than 100 mph on city streets can expect a $500 ticket from the cameras.
What sort of lunatic is going that fast on dense city roads, and why is it not escalating straight to an arrest warrant and a revocation of their driver's license?
Listen mate, the fact that you're even reading instructions at all instead of chucking the technical stuff aside, or trying to force some unlucky family member to be tech support, puts you miles above most of the people I've dealt with.
I had one guy demand I physically come down to his desk for an issue that was "blocking an important report". It was literally just Windows asking if he wanted to overwrite an old file.
I've been thinking of an electric motorcycle as well, for some of the longer commutes I do.But at the same time, I also want that cheap and tiny slate EV, for family trips. I saw one in person, it's definitely 1980s pickup small, and I really want to encourage the adoption of trucks that small.
As a bonus, it'll also confuse and frustrate the lifted gargantuan F-250 and 350 owners.
Amazing idea, but if the wiring in that second picture is anywhere near commonplace, you're going to want to put a bit more budget into power grid maintenance. That rats nest of cabling is bad enough from a low voltage IT perspective, I can only how terrifying that would be for HV engineers.
Branched way more than expected, and had to be brought home, repotted, and placed outside.Had to use some neem oil as well, a lot of bugs immediately started trying to use it as baby food.
It's an assisting tool, not the primary cleaning method. Blasts off bulk material and loosens up whatever's left, but you still need TP to finish the job. A lot less, but you still need some.As for lint, that happens regardless of the use of a bidet. Nothing changes there.
Heresy. Full stop. Do not pass go, do not collect $200. That church is run by heretics, and needs to be called out as such.
The red letter texts of Jesus' own teachings take precedent over any conflicting verses, and those teachings say to love thy neighbor as you would yourself.
I seriously hope that church has a nice big flat wall for someone to graffiti.
Huh, and I thought that was only for the os activation, but no. ESU support is right there, under the TSForge activation method.