Not a scientist, but if time were expanding I'm not sure how you would notice that subjectively. I imagine it would be like black hole time dilation. You'd still experience things at 1 sec per sec, it's just that your second is longer than an outside observer. But that's a wild guess by a relative idiot. Hopefully soon to be corrected.
Chemodynamic therapy (CDT) is an emerging cancer treatment that employs transition metal–based nanoagents to catalyze the conversion of elevated intracellular hydrogen peroxide in malignant cells into cytotoxic hydroxyl radicals (•OH) via Fenton-like reactions. Recent developments have also introduced CDT agents that generate singlet oxygen (1O2) through the Russell mechanism. However, current nanoplatforms efficiently produce either •OH or 1O2, but not both, and often exhibit suboptimal catalytic activity, thereby limiting the sufficient production of reactive oxygen species (ROS) required for cancer eradication. This report introduces a ferrous metal–organic framework, Fe(II)-TCPP (tetrakis(4-carboxyphenyl)porphyrin), as the first nanoagent capable of simultaneously and effectively generating •OH and 1O2 through dual catalytic pathways. Its nanoneedle-like morphology increases the surface area and promotes enhanced ROS production. Cell studies demonstrated selective intracellular generation of •OH and 1O2 in cancer cells, resulting in targeted cytotoxicity while sparing non-malignant cells. Systemic administration of Fe(II)-TCPP in a breast cancer mouse model resulted in preferential tumor accumulation, robust intratumoral ROS generation, cancer eradication, and prevention of recurrence without systemic toxicity. These findings mark a foundational advance in CDT nanoagents by integrating Fenton and Russell mechanisms into a single platform, enabling the design of multifunctional catalysts with enhanced ROS output and therapeutic efficacy.
Chemodynamic therapy (CDT) is an emerging cancer treatment that employs transition metal–based nanoagents to catalyze the conversion of elevated intracellular hydrogen peroxide in malignant cells into cytotoxic hydroxyl radicals (•OH) via Fenton-like reactions. Recent developments have also introduced CDT agents that generate singlet oxygen (1O2) through the Russell mechanism. However, current nanoplatforms efficiently produce either •OH or 1O2, but not both, and often exhibit suboptimal catalytic activity, thereby limiting the sufficient production of reactive oxygen species (ROS) required for cancer eradication. This report introduces a ferrous metal–organic framework, Fe(II)-TCPP (tetrakis(4-carboxyphenyl)porphyrin), as the first nanoagent capable of simultaneously and effectively generating •OH and 1O2 through dual catalytic pathways. Its nanoneedle-like morphology increases the surface area and promotes enhanced ROS production. Cell studies demonstrated selective intracellular generation of •OH and 1O2 in cancer cells, resulting in targeted cytotoxicity while sparing non-malignant cells. Systemic administration of Fe(II)-TCPP in a breast cancer mouse model resulted in preferential tumor accumulation, robust intratumoral ROS generation, cancer eradication, and prevention of recurrence without systemic toxicity. These findings mark a foundational advance in CDT nanoagents by integrating Fenton and Russell mechanisms into a single platform, enabling the design of multifunctional catalysts with enhanced ROS output and therapeutic efficacy.
“At this scale, downstream risks include account takeovers, targeted phishing, credit fraud, SIM swaps, and long-tail privacy harms. Industry-wide, the case underlines how third-party identity vendors have become critical infrastructure and can become single points of catastrophic failure,” our team explained."
I have an announcement play every 30 minutes to yell at me in a harsh voice "Drink Water God Damn It!"
I forget to hydrate a lot. I've tried many other reminders, but none of them worked well. Turns out I just need someone to yell at me.
"Unicorn Jelly is a philosophical science fiction manga strip which tells a metaphoric and purposeful story with a definitive beginning and ending.
It was published every weekday
at Midnight from 2000 to 2003."
I miss the old days of DA. Countless hours of scrolling to find the perfect wallpaper or art for my TTRPG games.
Now I mostly use Patreon or occasionally ArtStation. But it not the same.
Snow Crashed