If you liked Frieren, I highly recommend Violet Evergarden . It has very similar themes in how the protagonist is out of touch with humanity, but learns and grows through those around her. (Skip the second movie though)

Besides that, my list of general recommendations:

• Azumanga Daioh - 2002 classic about a bunch of high school students who are all idiots. That's it, that's the entire show. Endlessly quotable and extremely influential to 2000s era internet humor.
• The Apothecary Diaries - A medical drama set in imperial China (or a fictionalized version of it). The protagonist is unhinged in all the best ways.
• Bocchi the Rock! - A protagonist with cartoonishly overexaggerated social anxiety joins a band in the hopes of becoming popular. What really elevates this show above and beyond is the animation, whenever she starts imagining the worst of every situation, they take it to the extreme with live action, claymation, 3D modeling, paper cutouts, all manner of silliness.
• Kaiji - I'd like to recommend Akagi as my favorite series of all time, but Akagi is completely incomprehensible if you don't know anything about mahjong (and if you do know anything about mahjong, you already watched Akagi and you read the manga too so you didn't need me to recommend it to you). So instead here's another series by the same author that is understandable to general audiences.
• Kaguya-Sama: Love is War - Romcom about two idiots who clearly like each other, but they are idiots. They're both too stubborn to confess, instead believing that they have to get the other to fall for them and confess instead. This is one where you absolutely have to watch the dub, the narrator is amazing.
• Little Witch Academia - It's like if Harry Potter wasn't written by a terrible human being. I love the art style and character designs.
• Spy x Family - The first two episodes set up what appears to be a suspenseful thriller about a spy and an assassin, only to bait and switch with a delightful slice of life comedy about two absolute bozos trying to be good parents.