This is a bit of a cop-out answer, but the effects of HRT vary hugely based on the person. The "relief" you are feeling might be placebo, might be due to biochemical dysphoria, or a bit of both.

When I was on injections, I definitely felt a bit crappy at the end of the week, and a lot better about 30 minutes after my dose.

When I was getting my dose for patches worked out, I felt what I can only describe as "testosterone anxiety", which persisted as I slowly bumped up my dose over a couple of weeks and eventually went away when I got up to three patches. (Now I'm on spiro and back down to two, and things are fine). This was a different feeling to injections wearing off.

Now the only thing I notice is that I get four days of being really tired and bitchy pretty consistently every 25 days or so. I'm not going to speculate what that is, but since I'm on a very stable dose of two patches every two days, I don't think it's due to dosage.