• 0 Posts
  • 1.31K Comments
Joined 3 years ago
cake
Cake day: July 29th, 2023

help-circle
  • I mostly agree with you, but it’s not like overdoses caused by medical errors don’t ever happen either. Because it has a longer half-life (due to biological women commonly having a higher percentage of body fat compared to biological men, for example), medication levels can build up (as you mentioned) and result in adverse effects if you make a mistake with dosing. Pharmacokinetics and pharmacodynamics do matter too.

    Just because it’s not common (because physicians are trained to handle it appropriately) doesn’t mean it’s not possible.

    Like you said, demographics (including age, biological sex, etc) do matter.



  • Cisgender women have a naturally higher percentage of body fat than cisgender men, so lipophilic drugs have a larger volume of distribution in women. They sink into the fat tissue, stay in the body longer, and can take much more time to clear out. Overlooking sex-based variations in volume of distribution can be dangerous in an emergency situation, it absolutely can result in adverse drug reactions.

    That kind of information can be a factor in an emergency medicine situation, it’s not worth pretending that it’s not the case.

    Medicine is one of the areas where biological sex is actually relevant.