Skip Navigation

InitialsDiceBearhttps://github.com/dicebear/dicebearhttps://creativecommons.org/publicdomain/zero/1.0/„Initials” (https://github.com/dicebear/dicebear) by „DiceBear”, licensed under „CC0 1.0” (https://creativecommons.org/publicdomain/zero/1.0/)D

dgdft

@ dgdft @lemmy.world

Posts
7
Comments
246
Joined
11 mo. ago

  • 37 years since our homecoming queen was taken from us

    Jump

  • Weird crossover, but for the Twin Peaks fans who like EDM, Nicolas Jaar’s breakout DJ set samples this interview as its opener (and the whole thing is a banger end-to-end):

    https://youtube.com/watch?v=2h1h1JdaWGk

  • Deleted

    So, I was supposed to be a twin, but my twin was absorbed in the womb, which is known as "Vanishing Twin Syndrome", but i have a couple questions about this

    Jump

  • What you’re describing is a teratoma; vestigial twinning and chimerism don’t generally present that way.

  • The "western hemisphere" rubs me the wrong way

    Jump

  • The prime meridian roughly separates the two major clusters of land mass on the planet, which have undergone wildly different patterns of human settlement and development.

    The line itself is arbitrary, but the concept of the hemispheres as shorthand geopolitical labels for these geographic clusters is very much not arbitrary.

  • Removed Deleted

    Dangers of the privacy rabbit hole

    Jump

  • What’s the advantage of Extended Support Release?

    You get security updates without feature updates, basically. Meaning that you see fewer bugs and less overall change in exchange for missing out on bleeding edge additions you probably don’t care about.

  • Bacteria Frozen in Ancient Underground Ice Cave Found to be Resistant Against 10 Modern Antibiotics

    Jump

  • Even if we ignore any ethical concerns, when you’re sampling from an extreme environment, the strains you’re finding will, with >99.9% certainty, have substantially diverged from a biologically identical ancestor that’s spent a fair number of generations infecting hosts.

    So you also get a weird Ship-of-Theseus type question of “are these still really the same bacteria?”. And if you assume they are going to be different strains after adapting to different environments, then you can also safely assume that whatever strain you’re sampling in an extreme environment has a >99.9% probability of being in the potentially-harmful, contextually-harmful, or non-harmful bucket, by virtue of the fact you found it isolated in the wild rather than in living hosts.

    To put it a little more simply: if you’re looking for something with a demonstrated ability to infect people, you’ll probably find that inside or nearby people, not in an icy, remote cave.

  • Bacteria Frozen in Ancient Underground Ice Cave Found to be Resistant Against 10 Modern Antibiotics

    Jump

  • How are you distinguishing those ideas?

    Are we talking about “has actually been found infecting human patients”?

  • Bacteria Frozen in Ancient Underground Ice Cave Found to be Resistant Against 10 Modern Antibiotics

    Jump

  • It does to the target audience.

    What you’re missing is that Linnaean taxonomy breaks down when discussing bacteria, and the line between strain/species doesn’t really exist.

    Bacteria swap a lot of genetic material asexually, including across dramatically different species. Pathogenicity can also be dramatically modulated by presence of other species and environmental conditions.

    The idea of a particular strain or species of bacteria being inherently pathogenic in a binary yes/no way is a surprisingly flimsy and unhelpful one.

  • Bacteria Frozen in Ancient Underground Ice Cave Found to be Resistant Against 10 Modern Antibiotics

    Jump

  • It did.

    Psychrobacter SC65A.3 is a strain of the genus Psychrobacter, which are bacteria adapted to cold environments. Some species can cause infections in humans or animals.

    If it’s not immediately obvious: The intended takeaway is that this particular strain probably isn’t pathogenic itself, but it’s completely plausible that such resistance can spread via HGT to pathogenic species, within the genus or not.

  • I have questions and I'm afraid to ask them

    Jump

  • Probably wasn’t kosher RAW, but none of us had any idea what we were doing at the time.

    IIRC, we chose the bugbear because it was the only playable large option in the books we had (listed as med/large), but I could definitely be misremembering.

  • I have questions and I'm afraid to ask them

    Jump

  • In our case, it was the Ladder of Doom: a druid wildshaped into a warhorse mounted by a bugbear mounted by a human with a halfling on their back.

    Our DM forced us to roll checks and use our actions to mount up, but we did it anyway. Ladder strats were banned after that.

  • Microsoft 365's buggy Copilot 'Chat' has been summarizing confidential emails for a month — yet another AI privacy nightmare

    Jump

  • This part applies to all customers:

    v. Use of Your Content. As part of providing the AI services, Microsoft will process and store your inputs to the service as well as output from the service, for purposes of monitoring for and preventing abusive or harmful uses or outputs of the service.

    And while Microsoft has many variations of licensing terms for different jurisdictions and market segments, what they generally promise to opted-out enterprise customers is that they won’t use their inputs to train “public foundation models”. They’re still retaining those inputs, and they reserve the right to use them for training proprietary or specialized models, like safety-filters or summarizers meant to act as part of their broader AI platform, which could leak down the line.

    That’s also assuming Microsoft are competent, good-faith actors — which they definitely aren’t.

  • This MF is quadrupling down and dropping Alien files before dropping the full, unredacted Epstein Files. GODDAMN.

    Jump

  • Microsoft 365's buggy Copilot 'Chat' has been summarizing confidential emails for a month — yet another AI privacy nightmare

    Jump

  • This is some pathetic chuddery you’re spewing…

    You wouldn’t assume that QA can read every email you send through their mail servers ”just because”

    I absolutely would, and Microsoft explicitly maintains the right to do that in their standard T&C, both for emails and for any data passed through their AI products.

    https://www.microsoft.com/en-us/servicesagreement#14s_AIServices

    v. Use of Your Content. As part of providing the AI services, Microsoft will process and store your inputs to the service as well as output from the service, for purposes of monitoring for and preventing abusive or harmful uses or outputs of the service.

    We don’t own Your Content, but we may use Your Content to operate Copilot and improve it. By using Copilot, you grant us permission to use Your Content, which means we can copy, distribute, transmit, publicly display, publicly perform, edit, translate, and reformat it, and we can give those same rights to others who work on our behalf.

    We get to decide whether to use Your Content, and we don’t have to pay you, ask your permission, or tell you when we do.

  • Microsoft 365's buggy Copilot 'Chat' has been summarizing confidential emails for a month — yet another AI privacy nightmare

    Jump

  • Your general understanding is entirely correct, but:

    Microsoft is almost certainly recording these summarization requests for QA and future training runs; that’s where the leakage would happen.

  • Harm production

    Jump

  • bonded to a lipid

    It’s bonded to an amino acid, lysine.

    The lysine is cleaved from the prodrug in the bloodstream to release d-amph, not in the stomach. While I haven’t tried it (and wouldn’t recommend it), you should be able to get high from insufflation just fine, but the release curve will be much slower than if you were railing pure speed.

    Your friends weren’t talking out of their asses completely. Your psychiatrist isn’t talking out of their ass either, but they’re conflating the mechanism of action that Vyvanse uses with a mechanism used by many other prodrugs, which is first-pass metabolism.

  • He made beer that’s also a vaccine. Now controversy is brewing

    Jump

  • Then he should definitely know better and know why what he’s doing will ruin any chance he has of rapid certification.

    Asking naively: In what way would this self-experiment have bearing on later trials done by other parties?

    Setting aside the dangers of self-experimentation, there’s a host of issues ranging from the individual psychological (doctors are as vulnerable to sunk-cost fallacy as anyone) to broader problems of replication issues (publishing one-off successes/failures can lead to misinformation regarding the viability of a given therapy).

    IMO the main issue I saw in this case was administering to family members, to put my cards on the table, but I think given the risk profile, it was acceptable in context if they were well-informed and had an epipen handy.

    All research involves risk, and a key pillar of bioethics is the requirement of informed consent. Generally speaking, no one is better informed than a principal investigator to give that consent, and no one has better-aligned incentives to ensure safety.

    I also think any doing serious biomed research is well-educated enough to understand standards of evidence and treat small-N case studies for what they are.

    Ginseng, Garlic, St. John’s Wort, and Acai Berries underwent the same fad promotions.

    This is going too far in my book; wishful thinking is the problem here, not self-experimentation in a clinical context. I agree these supplements are overhyped, but do you really think we should be barring people from trying out garlic and reporting what they experience?

    The ethical issue in the case of grifter supplements is trying to financially profit from a contrived narrative, not the inherent process of trying things on a small scale and reporting those findings.

  • He made beer that’s also a vaccine. Now controversy is brewing

    Jump

  • But self-experimentation is a huge taboo in bio-ethics for a litany of reasons. If this guy was a proper professional, he’d know that.

    He’s a professional virologist with the NIH.

    Speaking from my own professional lens, I think the consensus around self-experimentation in biomed is way less black and white than you’re making it out to be. E.g., Dr. Barry Marshall famously won a nobel prize for self administering H. Pylori.

    What are your particular scruples in this case, if you don’t mind me asking?

  • What Functional Programmers Get Wrong About Systems

    Jump

  • It’s a bit wandering, but this piece has great insight on the whole and explains the motivations behind a lot of abstract modern tooling.

    As a grugbrained/anti-complexity type of designer, I was pleased that the author did such a good job aligning their arguments so that they were equally relevant to single-node hegemonic deployments just as much as Web-Scale (TM) microservice soup.

  • Rare, dangerous side effects of some COVID-19 vaccines explained

    Jump

  • That’s my question too: Why ignore the focus of the peer-reviewed research to latch onto a political talking point about how this isn’t significant because it impacts so few people?

  • History @lemmy.world
    dgdft @lemmy.world

    Dan Carlin’s Mania for Subjugation III Released (Alexander the Great series)

    dancarlin.substack.com /p/mania-for-subjugation-iii-now-available
  • Mycology @mander.xyz
    dgdft @lemmy.world

    Found my first wild edibles this summer in Vermont

  • Gardening @lemmy.world
    dgdft @lemmy.world

    Lemon Balm — Underrated?

    en.wikipedia.org /wiki/Lemon_balm
  • The Eternal Playlist @crazypeople.online
    dgdft @lemmy.world

    A.A.L. - Flash In The Pan

  • cats @lemmy.world
    dgdft @lemmy.world

    Sibling Personality Pic

  • Gardening @lemmy.world
    dgdft @lemmy.world

    Late April Garden

    imgur.com /a/cdVymtf
  • Gardening @lemmy.world
    dgdft @lemmy.world

    PSA: You can grow hot peppers as perennials

    imgur.com /a/oRscqpu