In the end the deciding factor is the supply and demand dynamic for someone like you in the job market. That is going to determine how picky you can allow yourself to be in your job search. Most people will try to use this dynamic to get a higher income, but you can also use it to get better working conditions etc. So you can look into jobs with a higher demand for applicants (searching job boards (1) and asking people who actively recruit can give you a feel for what is in higher demand), and you can look into jobs that have a lower supply of applicants (less populated areas, requiring rare qualifications, "unglamorous" fields that many aren't interested in or don't know about).

Of course stuff like asking the right questions during the interview, talking to employees, doing prior research etc. is important, but that only helps if you're in a situation where you can allow yourself to be picky because you have better options. So I'd focus on how to get into that situation if I were you.

At least, this line of reasoning has been very helpful to me. There's also people with different approaches that seemed to make them happy. Just something to think about.

(1) job boards are NOT very reliable sources of information, but they're a good start