My biggest regret is going with 32 of instead of 64GB of DDR5, when I built a new Ryzen 7000 PC in 2022 to replace my aging 4th gen i5.
But what I don't regret is ignoring everyone telling me not to do all sorts of unspeakable things to snag a $1600 4090 at launch, especially given that it was never sold that cheaply ever again. It's a beast of a card and I'll easily get a decade of gaming out of it. Saw 4090s going for over $3K used on eBay lately, so yeah I'm happy with making what was a dumb decision at the time.
It's been over 3 years now and I haven't had a single issue. I made sure to plug in the 12VHPR cable all the way and avoid bending it. I also made sure to buy a top tier PCIe 5 PSU.
The issue was vastly blown out of proportion. Don't be an idiot and you have nothing to worry about.