I use endevour on my main PC but bazzite in the laptop, which I barely use, so I wanted something that didn't mind not updating for a month and be fine, and bazzite nails that. I use distrobox for terminal things and vpn software for work is layered. No issues so far and very tempted to run it in my main PC, probably would do that if when arch breaks.
I use a yubikey (couldn't chose, it's from work) and I have no issues with it working out of the box (endevour os). I just touch the "button" and it "types" the key.
Omv, that is debian with a Web interface basically