I'm actually quite fond of a large screen, but it's not enough of a selling point for me to not go for this as my next phone. I have large enough hands that I don't struggle with reach on a large phone, so the main drawback is the additional battery power. But the fairphone has a swappable battery anyway, so that issue is more or less nullified.
My pet peeve is the front camera, I cannot wrap my head around the lunacy of having a large dead spot on the front of the phone, to the point I'd rather have a phone with no front facing camera than a big dead spot. People throw out screens for less.
Fairphone is almost the ideal phone for me, except this, and although I can probably remove the camera module, I can't swap the screen for one without the dead patch.
I'd have preferred a click lock of sorts, because in the cases I'm wanting to swap my battery, I'm probably on the move with no access to power / charging, such as hiking, coach rides, camping etc.
Currently I'm pretty happy with a portable charger but I'd much rather have one or two fully charged batteries, both for the speed of getting back to full charge and reducing the speed of battery degradation.
I'm already a big fan of having a minimalist daily carry, I have my phones with my bank cards on it, my house keys and maybe my camera or water bottle, and that's all. If be happy to shove a few spare batteries in a little case when I know I'll be out the house for some time, but a screwdriver is something I'd prefer to not have to carry every day.