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A person at age 40 (or 30 or any age) isn’t suddenly considered to be younger by anyone just because they’re infertile, in my experience. But heck, I don’t know; with all the anti-aging research going on, maybe we will be successful at ending age-related mortality in the next couple of centuries, and “old” would literally become just a truly relative number. For the time being, all I can say is that in my family and circles, about 35+ is considered not-young for any human, and especially 40+.
I appreciate how her head is slightly tilted in the other way so that the last panel isn’t simply an exact copy of the first (on her end of it, anyway).