The only cheating method that can’t be beaten reliably with any form of client side anti-cheat uses PCIe. The gaming PC gets a PCIe card that sends over data on RAM to a second PC over USB. That PC then turns all that data into useable info, and USBs it back to the gaming PC in the form of cheats/hacks.
I hope i got all that right, friend works in the industry and is studying this stuff. I can mostly keep up with all the things they tell me.
Every since May, I looked this up monthly to see if there is progress, only to have been met with 0 new info. Anxiously waiting!