Check out Tubular, a fork of Newpipe, which includes Sponsorblock and ReturnYoutubeDislike

Personally I find it a lifesaver for watching YouTube videos on mobile these days

There’s a project which is currently being completed for that scenario, the Mose: https://en.wikipedia.org/wiki/MOSE

It is directly supported and maintained from Google, which then bases Chrome on that project adding some proprietary code. So I think yes, it is doomed