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Barkeep

@ Barkeep @lemmy.world

Posts
8
Comments
12
Joined
4 wk. ago

  • Deleted

    Water Geometry and Resonant Shell Cosmology: How Holographic Encoding at Black Hole Event Horizons Establishes Universal Boundary Conditions

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  • Excuse me? Ask me if physics is understood. Thanks for your comment. Good health.

  • Woman sunlight 🤷‍♂️

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  • I definitely will. I have a bunch I've painted a sense I started a year ago.

  • Woman sunlight 🤷‍♂️

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  • Those are painting layered with packing paper. I was connecting speakers. This painting doesn't exist anymore. I kept fkn with after and it was a mess. It's a different woman now. I don't use models

  • An end to some of it

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  • It's one of my first pieces. It was an anger painting. The layers were chopped with a credit card. The credit card I hate lol.

  • Art Share🎨 @lemmy.world
    Barkeep @lemmy.world

    An end to some of it

  • Woman sunlight 🤷‍♂️

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  • Ok. Dude. It's paint made from pigmentation I found near the water front. I think it's good. I only began art around a year ago. She's dead. It happens

  • Art Share🎨 @lemmy.world
    Barkeep @lemmy.world

    Woman sunlight 🤷‍♂️

  • Deleted

    What do I think of my paper ? It's under review

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  • It's under peer review.

    This is one of my biology papers. It's been reviewed. It shows how simple my dataset are.

    Background and Evolutionary Context

    Human iris pigmentation varies widely across populations and is largely established during prenatal and early postnatal development. Genetic variation, particularly in regulatory regions near OCA2 and HERC2., explains much of this diversity. However, these genes primarily influence how pigment organelles develop and are organized , not whether pigment exists at all.

    Light-colored eyes, especially blue eyes, result mainly from **structural light scattering within the iris stroma, not from an absence of melanin. This makes iris color unusually sensitive to developmental microconditions that affect cellular organization.

    Water is the dominant component of embryonic tissues, including the developing eye. Importantly, the isotopic composition of water varies naturally with climate and geography. High-latitude and glacial environments are consistently depleted in deuterium relative to temperate and tropical regions. These isotopic differences are stable over generational timescales and therefore represent a plausible environmental variable during human evolution.

    Experimental studies in non-pigment cell systems show that altered deuterium-to-hydrogen (D/H) ratios can influence cellular metabolism, differentiation, and proton-coupled transport. However, the potential role of water isotopes in human developmental traits has not been systematically examined , particularly for traits dependent on cellular architecture rather than bulk chemistry.

    Central Hypothesis

     
            Variation in environmental deuterium levels during early development biases melanosome maturation and spatial organization in neural crest–derived iris melanocytes, producing heritable differences in iris light-scattering properties that act within genetically defined pigmentation limits.

    This hypothesis does not propose a new inheritance mechanism. Instead, it frames water isotopes as a , developmental modifier, that could contribute to population-level phenotypic patterns under stable environmental conditions.

    Rationale

    This hypothesis is supported by five established findings:

    1. Natural water sources show large, predictable geographic variation in deuterium content.
    2. D/H ratios influence cellular redox balance and proton-dependent processes.
    3. Iris melanocytes differ in regulation from skin melanocytes and show early developmental fixation.
    4. Melanosome pH, size, and maturation state strongly influence pigmentation outcomes.
    5. Structural light scattering, rather than pigment concentration alone, determines light eye coloration.

    Together, these observations suggest that even modest isotopic effects during development could produce visible phenotypic differences subject to evolutionary filtering.

    Specific Aim 1

    Determine whether developmental D/H ratios alter melanosome maturation and architecture in iris melanocytes.**

    Approach

    Neural crest–derived melanoblasts will be differentiated under controlled isotopic conditions representing low, typical, and elevated environmental deuterium levels. Outcomes will include:

    • Melanosome size and shape distributions
    • Relative proportions of immature and mature melanosomes
    • Intramelanosomal pH
    • Eumelanin-to-pheomelanin ratios

      Expected Outcome

    We expect D/H variation to bias melanosome architecture without necessarily changing total pigment production.

     
            Specific Aim 2

    Assess whether isotopically induced architectural changes modify optical properties relevant to iris color.

     
            Approach

    Using three-dimensional iris stromal models:

    • Quantify melanosome spacing and cellular organization
    • Measure wavelength-dependent light scattering
    • Relate structural parameters to optical behavior

      Expected Outcome

    Architectural shifts are expected to produce scattering profiles consistent with lighter or darker iris phenotypes.

    Specific Aim 3

    Evaluate interaction between isotopic effects and known pigmentation genetics in an evolutionary framework.**

     
            Approach

    Key experiments will be repeated using cells stratified by OCA2/HERC2 regulatory variants. This will test whether isotopic effects:

    Are consistent across genotypes Bias outcomes within genotype-specific pigmentation ranges

    Expected Outcome

    Results should support a gene–environment interaction model compatible with known evolutionary patterns of eye color variation.

     
            Evolutionary Significance

    If confirmed, this work would identify. stable environmental isotope gradients. as a previously unrecognized contributor to human phenotypic diversity. Such gradients could act as developmental filters, subtly shaping traits like iris pigmentation that are sensitive to microstructural organization.

    This mechanism would not replace genetic explanations but could help explain why certain pigmentation phenotypes emerge and persist in specific ecological contexts during human evolution.

    Summary

    This project tests a narrowly defined, physically grounded hypothesis: that water isotope composition influences the developmental architecture of iris pigmentation. By integrating cell biology, optics, and evolutionary context, it offers a conservative but novel framework for understanding variation in a classic human trait.

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    What do I think of my paper ? It's under review

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  • Im sorry dear. What do u want?

  • Deleted

    What do I think of my paper ? It's under review

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  • I've got u

  • Lemurian Frequency

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  • Gotcha ombre

  • Lemurian Frequency

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  • Why?

  • Lemurian Frequency

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  • Thats deep. Elaborate? She's not as cool as cartoon doodles by the looks of things here.

  • Art Share🎨 @lemmy.world
    Barkeep @lemmy.world

    Lemurian Frequency

  • Art Share🎨 @lemmy.world
    Barkeep @lemmy.world

    Light and feminine power

  • Art Share🎨 @lemmy.world
    Barkeep @lemmy.world

    Energy waves and light. Acrylic

  • Art Share🎨 @lemmy.world
    Barkeep @lemmy.world

    Lady riddles, Acrylic.