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Cake day: June 9th, 2023

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  • AlolanYoda@mander.xyztoScience Memes@mander.xyzHELP HIM.
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    1 month ago

    We can probably never get rid of animal testing entirely for clinical research, we’ll always need to validate simulations in animals before moving on to humans.

    Getting rid of animal testing is the exact purpose of organ-on-a-chip research! This is actual bioengineered cultures, not simulations (not dissing on computational biochemistry - also extremely important)

    If you can test without the full animal, then models (in this context, models = what you use for testing, be it cultures or animals) based on human induced pluropotent stem cells (ie cells taken from live, adult humans and forced to revert to a stem cell status) in an in vitro setting can actually be more relevant to human physiology than live animal models.

    There are a lot of caveats (if it were easy, it would already be done), and there are barriers needed to be overcome for in vitro models to even come close to in vivo and ex vivo models. But a lot of people are investing in it, not (only) due to ethics but also due to lower model cost and better match of in vitro results with the actual effect on a live human body.

    I can give papers when I get home, if you want.

    Edit: I went on a deep dive on medical applications: suffice it to say, this is useless for behavioral experiments






  • AlolanYoda@mander.xyztoMemes@lemmy.mlEveryone's Dream
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    2 months ago

    I had appendicitis and barely noticed. I just felt like I had a mild case of gas for 3 days. I was lucky that I was with my ex at the time and she got worried, otherwise I might be dead and would barely have cared.

    But then the year after that I broke my back and also only cared to go to the doctor after one month, so maybe I’m not the best example



  • My input: I’ve never searched for papers in Scihub directly. I usually find them off Google scholar or something, and then put the paywalled URL or the DOI (an identifier you can usually find in the paywalled website) in Scihub to go to that paper. I don’t think search capabilities are in scihub’s scope.








  • There are a lot of games tied to popular IPs stuck on J2ME! Usually of questionable quality, though. There are half a million Sonic games, including a version of Sonic Unleashed that if I recall correctly played something like Sonic Rush, a Ratchet and Clank sidescroller (is it called Going Mobile maybe?), I also remember Tomb Raider games there. I would love to look at an overview of the most interesting games in this platform. It is extremely nostalgic to me.

    I also have no clue how they were distributed? I remember putting them on my phone using less than legal means, but have no idea how you’d get them officially. Was it through one of those sketchy services where you could also get wallpapers and ringtones by texting a specific number?