8mo ago

MD PhD Cywes' theory on LMHR and Carnivore suppression of GLP-1 as a bad thing (i.e. Paul Saladino Syndrome)

I don't agree with Cywes, he gives off the impression of being very confident on his speculations but the theory he presents is worth discussing.

If I understand it correctly -

LMHR Carnivores have low GLP-1 Response to food
This accounts for the increase in LDL
This is a risk? (he wasn't super clear) for carnivores
People in this LMHR Carnivore setting should eat carbohydrates (20-50g) to prevent the LMHR phenotype for optimal health

This appears to mirror Paul Saladino's experience where he wasn't getting enough insulin secretion on his carnivore diet.

Other's in the Carnivore space MD Baker/PhD Bart Kay - have spoken of needing a large enough protein bolus to trigger a insulin response. Whey Isolate has been recommended as a possible trigger for people having trouble eating enough protein.

We are well outside of the literature and measured clinical trials. We are deep into mechanistic speculation land.

I don't agree with Cywes the LMHR group has elevated risk, and the study he references while not being conclusive is also a prospective matched epidemiological study.

What are your thoughts on engineering insulin spikes?

summerizer

WHY ARE CARNIVORES AT RISK FOR HEART ATTACKS?

Dr. Robert Cywes discusses the findings of the LMHR study, which indicates that individuals on a carnivorous diet are at the same risk for heart disease as those on a standard American diet. He elaborates on how high cholesterol and LDL levels do not correlate with plaque formation, while also pointing out possible increases in soft plaque among lean mass hyperresponders. The video emphasizes the importance of insulin resistance and insulin sensitivity, rather than just cholesterol levels, in understanding heart disease risk.

Key Points

LMHR Study Overview

The LMHR study, led by Dr. Feldman and others, analyzes individuals classified as lean mass hyperresponders who have high LDL and low triglycerides. The study found that high cholesterol does not correlate with increased cardiovascular risk.

Soft Plaque Formation

Contrary to expectations, the study revealed that lean mass hyperresponders experienced an increase in non-calcified plaque volume over time, aligning their risk of plaque progression with those consuming a standard American diet.

Cholesterol vs. Insulin Resistance

Dr. Cywes highlights that the real issue is not elevated cholesterol levels but rather insulin resistance caused by carbohydrate intake, suggesting that plaque formation may be a result of insulin suppression in carnivorous individuals.

Importance of GLP-1

GLP-1 plays a crucial role in insulin regulation, and its insufficient triggering in a strict carnivore diet can lead to elevations in blood sugar and insulin resistance, which may produce vascular inflammation and plaque.

Diet Recommendations

The doctor argues for the reintroduction of small amounts of carbohydrates in diets for those with insulin suppression to help prevent plaque formation and maintain healthier metabolic function.