Researchers then compared the answers of those who received HRT between ages 14 and 17 to those who received HRT at age 18.

“The average association between [HRT] and the risk of running away is a decrease of 2 percentage points, which constitutes a 20% decrease relative to the baseline rate
of running away,” researchers wrote.

A 2026 study found that trans youth who get HRT are less suicidal. A 2025 study found that gender-affirming medical care has positive effects on the mental health and psychosocial functioning of trans youth. A 2024 study found that 97% of trans youth didn’t regret transitioning, even a decade after receiving such care, and another study that same year found that only 1% of trans teens detransition. A 2023 study also found that HRT improves mental health for trans youth.