Would US separatist movements be possible and/or advisable?

I was thinking about it recently, and this is just a random thought I had it's not well developed, but I was Watching something on the uptick in separatist parties in the UK, and given the massive geographical range of the US I was wondering if separatist movements would be helpful.

This could be any separtist movement, from Chicano and African to Indigenous to Cascadian. I just feel like independence from the US is a lot more feasible in the short term rather than some form of revolution overtaking the whole country all at once. But like I said, it's an undeveloped thought (although I would prefer answers more than "i love balkanization" and "America is bad so yes." It's less a question of "is hurting america good" and more "is this the best way to do it?")