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Posts
2
Comments
67
Joined
3 yr. ago

  • Your first interpretation wasn't the case in this specific ad, because the "minimum 5-10 year experience" was on the list of "essential experience and skills" and there was a separate list of "desirables".

    Your second explanation just supports my original infuriation - just state the range that you're interested in, without calling it a minimum.

    Actually, I got that job, I'm still working for the company, but to your last point, I have to say it's hilarious how bad our communications dept is at communicating to the rest of the company.

  • Or just give the range.

  • 3 days.

  • Not just Amazon. I had a parcel being delivered by DPD while I was on holidays. I checked the delivery's webpage, which said "if you're not in, we'll leave it with your neighbour". Great!

    While I was on holiday, I checked the status on the day of delivery: "you weren't in, we returned it to DPD depot". Somewhat annoying, but the depot is only 15 minute drive from mine, I can go collect it then I'm back home.

    Checked it again when I got back home: "returned to sender".

    The fun thing was that the item was the modem from my new internet provider, and my old provider was ceasing their services that very day.

  • I honestly have no idea what your first paragraph is about. It might as well be in Chinese.

    I'm a molecular biologist. I was recently surprised when I told someone that RNA is a thing that all living thing are brimming with. He thought that RNA was something scientists invented in 2020s to use as COVID vaccines.

    I also once worked with someone who had a degree in biological sciences and was shocked to learn that female cows have vaginas. She didn't explain where she thought baby cows come from, but we decided not to push the matter and changed the subject.

  • Of course I noticed! It's really annoying for a creature of habit like me :(

  • That was my thought when I started reading the piece. "Are we just going to call it XFT?"

  • I'm also a non-native speaker and I've also been taught to speak a certain way ("you and I are going" but "he saw you and me"; don't split infinitives; don't end sentences with prepositions, etc.), but then I read Steven Pinker's The Language Instinct and - even more relevant here - The Sense of Style. We've been taught to use language a certain way, but our teachers were following the prescriptivist school of thought. You say these rules were written by native folk, but it's often (if not usually) the native folk that say less when they "should" be saying fewer.

    I know you said it's only mildly infuriating to you, but if proper use of language is something dear to your heart (as it is to mine) - I really recommend the above books as I think this is something not worth to get even mildly infuriated about. The border between less and fewer is fuzzier than you think and - in the words of Pinker - once you really master the distinction - that's one fewer thing for you to worry about.

    Edit: typo

  • Thanks for explaining this. I'm a childless guy living in the UK in a big city, close to many big markets and specialty stores, so I guess my experience is totally different than what you're describing and you gave a few pretty good reasons why there's such a gap in how much the convenience of Prime is worth for someone like you and someone like me. I guess the article just isn't aimed at people like me.

  • Probably not the comment you were expecting, but, what's "sad sigma male music"? And why is it called that?

  • Wow, never thought I'd see a headline like this. I've never had Amazon prime except for the free month trial. I had no idea it was such a problem for others that there are articles written about it.

  • Maybe you should cook some food and deliver it to your local KFC - would that count?

  • is overhearing and joining random conversations a business plan?

    That really made me laugh. No, of course it's not a business plan. I was just trying to make a point that there are benefits to people being together in the office.

  • This is probably going to be an unpopular comment, but I wanted to present the view in favour of what I call WFW (working from work). I'm sure it's always going to be different for specific cases, but I do see benefits of WFW. We have an open plan office and a lot of casual conversations between us turn into serious conversations about projects and sometimes they have important outputs. Sometimes you overhear a conversation that you realise you know something about and you make a valuable contribution to it. None of this happens when people are WingFH. I'm lucky enough that my only line report is a hard working person, so I let them WFH probably a bit more than other managers let their reports, but I still like when they are WFW because of the contributions that they make to those conversations I mentioned above.

    I'm an introvert, so I totally get the argument of being able to focus better when you're not surrounded by people and their conversations, but at the same time I honestly noticed that my productivity decreases when I WFH. I'm sufficiently honest with myself to notice that and feel bad about it and this is actually the main reason why I do commute for an hour every day just to WFW, even though our company policy says that we can WFH 3 days a week and my job is 95% desk based.

    I think it's often has to considered for individual cases because as I said, my report does 110% whether they WFH or WFW, but I know from other managers that some of their reports really stuttered and stumbled when they were asked "so you WedFH yesterday, what did you do exactly?"

    I'm not trying to say "everyone should stop WFH", but it seems to me that most of the comments in this post are aligning with "just let your employees WFH!" and I wanted to present the other point of view, from the perspective of a non-senior manager who also has some non managerial responsibilities himself.

  • So glad that Brexit brought the control back to our own hands!

  • Of course it needs to be controlled and regulated. Like any other drugs. One of the reasons drugs are expensive is because there is so many regulatory hurdles that drug makes have to deal with before they can touch a patient.

    I get your hypothetical, but it has two shortcomings. Firstly, training the immune system against cancer mutations is fairly easy, because the mutations are not present during the process of T and B cell maturation, so in the population of circulating naive T and B cells in a patient, there are likely to exist ones that are going to recognise the cancer antigen. Whatever proteins drive the dark pigmentation of skin or green eye colour will be used to drive the negative selection of T and B cells in the person with dark skin or brown eyes. And so, even if you administer a "vaccine" encoding these proteins, their immune systems will not be able to mount a response against them.

    Secondly, what about the practicalities. Say you made the anti-green eye vaccine - how do you administer it to people? I'm assuming we're not talking about some dystopian future where forcing people to receive injections that contain biologicals killing them is legal. It's not the kind of "vaccine" that you could just spread in the air or add to drinking water for it to take effect.

  • I think the first point to make is that this is not really the patient's own genetic information, but that of their cancer, something they desperately want to get rid of. And the second point is that to my knowledge, there is no county on earth, where taking part in a clinical trial would not require the patient's consent, which is to say, all people in the study were informed that the genetic sequences of their cancers will be analysed and used to generate a vaccine.

    As for the potential to become a weapon, you would have to elaborate, because I really don't see how the Moderna vaccine strategy could be weaponised.

  • In general, mutations can happen anywhere on any gene, so every patient's cancer will have its unique signature of mutations. However, like in the evolution of organisms by natural selection, most random mutations will have a detrimental effect and the cells carrying it will die. Some of the mutations will be neutral and despite the change in the amino acid, the cells harbouring it won't survive better or worse than cells that don't have it. But a few mutations will make the cancer cells proliferate faster or evade the immune system better, which will lead to these cells surviving and ultimately overtaking the population of the cancer cells. The latter mutations often happen in the same places on the same genes, and in melanoma for example, in as many as 41% of cases the 600th amino acid in a protein called BRAF mutates from valine to alanine (so the code for that mutation is "BRAF V600E"), and BRAF is only one example of such genes that commonly mutate in the same position.

    So to answer your question - I don't know Moderna's exact protocol, but my guess is that the tailored vaccine will contain a mixture of these commonly occurring mutations and some mutations that are unique to the patient.

  • I think you're amazing. Having faced such tremendous adversities at such young age, you still think that the main message you need to share is that life is fucking incredible.

    I'm not a blogger or anything, so I'm sorry for posting a comment without any answers to the question in the title. But if the outlet you choose ends up being publicly available, please share the link. I would love to read whatever you think is worth writing down.