💯%. the US was heavily isolationist at the start of WWII, and pretty anti-Semitic. for example, the St. Louis, a boat full of Jewish refugees, was turned away from the US and Canada in 1939 - and turned back to Europe, with many Jews eventually imprisoned and murdered by the Nazis. there were also the blackshirts in the UK, who were pro-Nazi, and PM Chamberlain had a peace treaty drawn up with Hitler. and the Molotov-Ribbentrop pact with the Soviets, of course.
so if the Nazis had been content to murder only German, Austrian and Czech Jews, they would have gotten away with it.
on the other hand, Nazi ideology (e.g. "lebensraum" and their belief in the destiny of the Aryan race to conquer the "inferior" races) drove them to war, to invade Poland and to break their pact with the Soviets. and they also spent tons of resources on the Holocaust, at the expense of their military.
so basically yeah, isolationist Nazis would have totally survived, but otoh Nazis aren't isolationists.
definitions:
Alligator Auschwitz is a concentration camp because it's 1) massive, 2) full of the same type of prisoner (ethnic minority migrants), 3) who can't leave. it's not yet a death camp, but most Nazi camps weren't death camps (they centralized that!)