Prismlauncher has a similar issue, basically you have to sort of "convert" the Ubuntu instructions, thankfully there's a flatpak.
The album I just released was made with mostly open-source tools, in particular LSP, Calf Studio Gear, and x42 were all made for Linux, and the two non-FOSS plugins (Graillon and Acon Digital Multiply) ran fine with yabridge.
Makes you wish for nuclear winter