I know enough physics to say no Even inter-Stellar is out of our reach (without generation ship).
We have zero reason to believe in an effective way to build wormhole, jump gates or anything similar. Even high energy cosmic rays have a limited range (due to collision with photons) which is a strong clue that there is no shortcut in space









The very slow is the issue. Assuming we can reach 10-20% of c, we can reach a couple of nearby stars in 200 years (Wikipedia gives me 50 stars with 30 ly).
200 years is roughly the time from the Napoleonic era from today (Taking an Euro reference). Do you remember what your ancestor were doing during Napoleon Russian campaign or when US purchased Louisiana?
Society changed massively since Napoleon. Over 200 years the society culture of a generation ship would also drastically diverge from ours. Moreover, I can't think of many piece of technology which can keep working for 200 years without a few massive overall.