Yeah, the studies generally point to a cumulative effect. Basically the aldehyde byproduct of alcohol breakdown is also poisonous. It can lead to cancer growths so arguably binge drinking is worse in that respect because it takes longer for everything to clear.
Interestingly, if there was a way to break that aldehyde down faster, then the cancer risk might go down significantly. It's just not super clear at this point.








Tolerance is a real thing and can be developed over time. However it's not clear if that has any relation to cancer risk, which appears to be related to ability to clear the aldehyde byproduct.