Yes, with a virtual machine. But the experience will not be the best because the VM will lack a GPU.
I'm sure there is ways to share some resources of the GPU with the VM to have a smoother experience but I have never done that on Windows
You can play some games with anticheat. But not the biggest ones like CoD, Valorant or any borked game in ProtonDB. In my case I only play BattleBit Remastered, it uses EasyAntiCheat, apex also works. I don't really care about games now, if a game doesn't support my system, then I will not buy it nor play it. (Like league of legends)
EasyEffects exists, there is something called Catia or Carla which it can be use to run VSTs IIRC. But I am not an audio pro on linux or something like that.
Because they do not care about you