Recommended operating system for self-hosting on a VPS?

Requirements:

• based on Debian GNU/Linux
• easy to install/uninstall services

Services I'm interested in:

• several crypto nodes: BTC, BCH, ETH light node (Helios), XMR, ZEC, etc.
• Nostr
• SimpleX
• xBrowserSync
• taskwarrior
• Synchthing
• Mastodon
• vdirsyncer
• Element/Matrix

Is using containers with docker/podman on plain Debian the best approach for simplicity?

Does it make sense to have more than one VPS? E.g. one for crypto nodes and another one for the rest?