Scientists revive activity in frozen mouse brains for the first time

Researchers attempting the cryogenic freezing and thawing of brain tissue from humans and other animals — mostly young vertebrates — have already shown that neuronal tissue can survive freezing on a cellular level and, after thawing, function to some extent. But it has not been possible to fully restore the processes necessary for proper brain functioning — neuronal firing, cell metabolism and brain plasticity.

A team in Germany has now demonstrated a method for cryopreserving and thawing mouse brains that leaves some of this functionality intact. The study, published on 3 March in Proceedings of the National Academy of Sciences, details the authors’ use of a method called vitrification, which preserves tissue in a glass-like state, along with a thawing process that preserves living tissue.